NOD2 nucleic acids and proteins
AssigneeThe Regents of the University of Michigan
InventorsGabriel Nunez, Naohiro Inohara, Yasunori Ogura
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Abstract
The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
Claims14
An isolated and purified nucleic acid comprising a sequence encoding a protein selected from the group consisting of SEQ ID NOs:
- 2,3 and 34.
An isolated and purified nucleic acid sequence that hybridizes under conditions of low stringency to a nucleic acid selected from the group consisting of SEQ ID NO:
- 1 and 33.
10-15. (canceled)
A nucleic acid encoding Nod2, wherein said Nod2 competes for binding to RICK with a protein encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 1 and 33.
(canceled)
19-26. (canceled)
Dependencies are inferred from the claim text.