Toll-like receptor
AssigneeYale University
InventorSankar Ghosh
Life of this patent
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Abstract
The invention describes isolated Toll-like receptor 11 (“TLR11”) polypeptides as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding a TLR11 polypeptide and methods for producing a TLR11 polypeptide. Also described are methods for screening for compounds which modulate TLR11 activity and methods of use of TLR11 polypeptides as adjuvants.
Claims24
An isolated nucleic acid comprising a nucleic acid sequence selected from the group consisting of:
- a nucleic acid which is represented by SEQ ID NO:
- 1;
- a nucleic acid sequence that is at least 70% identical to the nucleic acid sequence of SEQ ID NO:
- 1;
- a nucleic acid sequence which is represented by the complement to SEQ ID NO:
- 1;
- and a nucleic acid sequence that is at least 70% identical to the complement of the nucleic acid sequence represented by SEQ ID NO:
- 1.
An isolated nucleic acid that hybridizes under high stringency conditions to the nucleic acid represented by SEQ ID NO:
- 1 or to its complement.
An isolated nucleic acid comprising a nucleic acid sequence that, due to the degeneracy of the genetic code, encodes the amino acid sequence encoded by the nucleic acid sequence depicted in SEQ ID NO:
- 1.
An isolated Toll-like receptor polypeptide comprising an amino acid sequence selected from the group consisting of:
- an amino acid sequence that is at least 70% identical to the amino acid sequence depicted in SEQ ID NO:
- 2;
- an isolated Toll-like receptor polypeptide comprising an amino acid sequence that is at least 95% identical to the amino acid sequence depicted in SEQ ID NO:
- 2;
- and an isolated Toll-like receptor polypeptide comprising an amino acid sequence that is represented by SEQ ID NO:
- 2.
A vector comprising nucleic acid sequence encoding a polypeptide that is at least 70% identical to the polypeptide represented by SEQ ID NO:
- 2.
Isolated host cells comprising exogenous nucleic acid encoding a polypeptide that is at least 70% identical to the polypeptide represented by SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.