Device and methods for concentrating prion protein isoforms
OwnerBrian Zeiler, Abraham Grossmaninventors
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Abstract
Disclosed herein are a device and methods used to interact with proteins. In particular, a device, compositions and methods used to concentrate and detect prion proteins within a sample.
Claims34
A composition comprising a nucleic acid ligand affixed to a support, said nucleic acid ligand having affinity for prion protein.
A device for isolating prion protein, comprising
- a vessel for containing a sample and a support;
- and a support, wherein said support has a nucleic acid ligand affixed thereto, said nucleic acid ligand having affinity to prion protein such that sample potentially containing prion protein may be placed in said vessel and said prion protein, if present, bind to said nucleic acid ligand.
A kit for concentrating prion protein in a sample, comprising a nucleic acid ligand affixed to a support, said nucleic acid ligand having affinity for prion protein.
A method of concentrating prion protein comprising the steps of providing a nucleic acid ligand affixed to a support, said nucleic acid ligand having affinity for prion protein and placing a sample in contact with said support under conditions in which said nucleic acid and prion protein form an affinity complex.
Dependencies are inferred from the claim text.