Lipid-based dispersions useful for drug delivery
OwnerNing Hu, Gerard Jensen +2inventors
InventorsNing Hu, Gerard Jensen, Stephanie Yang, Su-Ming Chiang
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Abstract
The invention provides lipid-based dispersion comprising comprising, a) phosphatidyl choline; b) an anionic phospholipid; optionally c) up to 1% cholesterol by weight of total lipids; and optionally d) a therapeutic agent; wherein the mean particle size measured by dynamic light scattering is less than 100 nm. The invention also provides pharmaceutical compositions comprising such a dispersion as well as methods of producing a therapeutic effect in a mammal comprising administering an effective amount of such a dispersion.
Claims31
A lipid-based dispersion comprising, a) phosphatidyl choline;
- b) an anionic phospholipid;
- optionally c) up to 1% cholesterol by weight of total lipids;
- and optionally d) a therapeutic agent;
- wherein the mean particle size measured by dynamic light scattering is less than 100 nm.
Dependencies are inferred from the claim text.