Coating for implantable devices and a method of forming the same
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsSyed Hossainy, Steven Wu, Manish Gada, Anthony Andreacchi
Life of this patent
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Abstract
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
Claims56
An implantable device comprising a coating for delivery of an active ingredient, wherein the coating includes:
- a primer region comprising a polymer on at least a portion of a surface of an implantable device, wherein the primer region has a thickness X;
- a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region, wherein the reservoir region has a thickness Y;
- and
- wherein the thickness X is measured from the outer surface of the primer region to the surface of the implantable device prior to the migration of the active ingredient from the reservoir region to the primer region, and
- wherein
- (a) the thickness X is about 0.1 microns to about 10 microns and the thickness Y is about 0.5 micron to about 10 microns,
- (b) X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05, or
- both (a) and (b).
A method of forming a coating for an implantable device, comprising:
- forming a primer region comprising a polymer on at least a portion of a surface of an implantable device wherein the primer region has a thickness of X;
- forming a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region wherein the reservoir region has a thickness of Y;
- and
- wherein
- (a) the thickness X is about 0.1 microns to about 10 microns and the thickness Y is about 0.5 micron to about 10 microns,
- (b) X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05, or
- both (a) and (b).
An implantable device comprising a coating for delivery of an active ingredient, wherein the coating includes:
- a primer region comprising a polymer on at least a portion of a surface of an implantable device, wherein the primer region has a mass X;
- a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region, wherein the reservoir region has a mass Y;
- and
- wherein
- X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05.
A method of forming a coating for an implantable device, comprising:
- forming a primer region comprising a polymer on at least a portion of a surface of an implantable device wherein the primer region has a mass X;
- forming a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region wherein the reservoir region has a mass Y;
- and
- wherein X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05.
An implantable device comprising a coating for delivery of an active ingredient, wherein the coating includes:
- a primer region comprising a polymer on at least a portion of a surface of an implantable device, wherein the primer region has a mass X;
- a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region, wherein the reservoir region has a mass Y exclusive of the active ingredient;
- and
- wherein
- X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05.
A method of forming a coating for an implantable device, comprising:
- forming a primer region comprising a polymer on at least a portion of a surface of an implantable device wherein the primer region has a mass X;
- forming a reservoir region comprising a polymer and an active ingredient on at least a selected portion of the primer region wherein the reservoir region has a mass Y exclusive of the active ingredient;
- and
- wherein
- (i) X/Y is selected from the following ranges:
- 0.01 to 0.2;
- 0.05 to 0.2;
- 0.01 to 20;
- 0.05 to 20;
- 0.01 to 1;
- 0.05 to 1;
- or 0.01 to 0.05.
Dependencies are inferred from the claim text.