Pharmaceutical compositions containing extracted MHC molecules, for stimulation of the immune system
OwnerAngele Turianoinventor
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Abstract
Allo-, iso- and xenoantigens, chosen from histocompatibility molecules obtained by extraction from homogenates of tissues or cells with Nonidet P40 or 1 N HClO4, are disclosed for use as a medicament for stimulation of the immune system of man and mammals, and in particular for cancer therapy.
Claims18
1-16. (canceled)
A kit useful for the treatment of a carcinoma in a patient, comprising at least two containers, each comprising an extract from an animal tissue, serum or cell source wherein said extracts
- a) comprise allogeneic or xenogeneic MHC molecules;
- b) are prepared by a) homogenizing the tissue, serum or cell source in the presence of NP40, or b) treating said source with an acid, or c) treating said source with a proteolytic enzyme;
- and
- c) are each effective to reduce the number of tumor cells in the patient compared to the number of tumor cells if the patient is not so treated,
- wherein the source of the extract in one container is from i) a tissue, serum or cell different from the tissue, serum or cell for the other container, and from the same animal;
- ii) a tissue, serum or cell from a different animal of the same species as the animal source for the other container;
- or iii) a tissue, serum or cell from an animal from a different species as the animal source for the other container.
A method for the treatment of a carcinoma comprising administering to a patient at least two doses of extracts from an animal tissue, serum or cell source, wherein each of said extracts
- a) comprises allogeneic or xenogeneic MHC molecules;
- b) is prepared by a) homogenizing the tissue, serum or cell source in the presence of NP40, or b) treating it with an acid, or c) treating it with a proteolytic enzyme;
- and
- c) is effective to reduce the number of tumor cells in the patient compared to the number of tumor cells if the patient is not so treated and
- wherein one of said extracts is extracted from an animal tissue, serum or cell source and the other is extracted from a different such source, wherein each of said doses is in an amount effective to reduce the number of tumor cells in the patient compared to the number of tumor cells if the patient is not so treated.
A kit useful for the treatment of a carcinoma in a patient, comprising at least two containers, each comprising an amount of MHC molecules which may be found in extracts from an animal tissue, serum or cell source, wherein said extracts
- a) comprise allogeneic or xenogeneic MHC molecules;
- b) are prepared by a) homogenizing the tissue, serum or cell source in the presence of NP40, or b) treating said source with an acid, or c) treating said source with a proteolytic enzyme;
- and
- c) are each effective to reduce the number of tumor cells in the patient compared to the number of tumor cells if the patient is not so treated,
- wherein the source of the extract in one container is from i) a tissue, serum or cell different from the tissue, serum or cell for the other container, and from the same animal;
- ii) a tissue, serum or cell from a different animal of the same species as the animal source for the other container;
- or iii) a tissue, serum or cell from an animal from a different species as the animal source for the other container.
Dependencies are inferred from the claim text.