Endotoxin-binding ligands and their use
AssigneePrometic Biosciences Inc.
InventorsSteven Burton, Tadeusz Podgorski, Saji Eapen
Life of this patent
Estimating the term…
Abstract
An affinity ligand-matrix conjugate of the structure Z-Spacer-[NX-A]m-NY-A-NK2 is useful for the isolation, separation, purification, characterization, identification or quantification of endotoxins in an aqueous system, wherein m is an integer of at least one; each A independently represents an optionally substituted linear, branched or cyclic saturated hydrocarbon chain containing 1 to 6 carbon atoms; each X independently represents hydrogen or alkyl; Y is X or A-NX2; and Z is a support matrix attached to the ligand through an optional spacer arm (Spacer).
Claims12
A method for the isolation, separation, purification, characterization, identification or quantification of endotoxins in an aqueous system wherein said method comprises the use of an affinity ligand-matrix conjugate of the structure
- Z-Spacer-[NX-A]m-NY-A-NX2
- wherein
- m is an integer of a least one;
- each A independently represents an optionally substituted linear, branched or cyclic saturated hydrocarbon chain containing 1 to 6 carbon atoms;
- each X independently represents hydrogen or alkyl;
- Y is X or A-NX2;
- and
- Z is a support matrix attached to the ligand through an optional spacer arm (Spacer).
Dependencies are inferred from the claim text.