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OwnerJuan Aragon Reyes, Alfonso Fernandez-Mayoralas Alvarezinventors
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The invention relates to the use in humans of a method which is based on the use of 4-galactosyl-xylose and which involves an alternative technique to evaluate xylose in urine. The method consists of measuring the concentration of xylose in the blood following the oral administration of 4-galactosyl-xylose to the patient, the use of said method being even more suitable in the case of newborns. The invention also relates to the technology used for the in vivo evaluation of intestinal lactase activity, by way of a non-invasive test for the diagnosis of a deficiency of said enzyme, which consists of directly evaluating the overall activity of the enzyme in the individual and not in assessing the consequences of said deficiency. The inventive method does not require specialized equipment, does not cause any obvious discomfort to patients with a lactase deficiency and is extremely reliable, thereby eliminating the inconveniences of currently used diagnostic tests.
- A method for determining the presence of xylose in urine, usable for in vivo evaluation of intestinal lactase as a diagnostic test of the deficiency of this enzyme, that comprises oral administration of an aqueous 4-galactosyl-xylose solution to an individual who has fasted for at least 8 hours and the evaluation of the amount of xylose present in urine.
- A method according to claim 1, wherein the amount of xylose present in urine is calculated by means of the difference found between the measurement made in an aliquot coming from the total volume of urine collected after the intake of 4-galactosyl-xylose and the measurement made in an aliquot coming from the volume of basal urine collected immediately before the individual intakes this compound.
3) A method according to claim 1, wherein the individual is a human being.
4) A method for determining the presence of xylose in blood, useable for in vivo evaluation of intestinal lactase as a diagnostic test of the deficiency of this enzyme, which comprises oral administration of an aqueous 4-galactosyl-xylose solution to an individual who has fasted for at least 8 hours and the evaluation of the amount of xylose present in blood.
8) A method according to claim 1, that in human individuals permits carriers of intestinal lactase deficiency from being distinguished from those individuals who are allergic to some component of milk, but who are not carriers of a deficiency of this enzyme.
Dependencies are inferred from the claim text.