Method for preserving organs for transplantation with a HGF-containing solution
OwnerYoshiki Sawa, Hikaru Matsuda +2inventors
InventorsYoshiki Sawa, Hikaru Matsuda, Toshikazu Nakamura, Shinya Mizuno
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Abstract
A method of preserving a harvested organ, a harvested organ tissue or a part thereof for a long time, which comprises perfusing and/or immersing the harvested organ with a solution containing HGF having a temperature of 0 to 6° C., and which method is capable of maintaining harvested organs for transplantation in a high physiological state and preventing ischemia/reperfusion injury of the organs transplanted.
Claims20
a method for preserving a harvested organ, a harvested organ tissue or a part thereof, which comprises bringing various organs, organ tissues or parts thereof from living or dead bodies into contact with a solution containing hepatocyte growth factor (referred to as HGF) having a temperature of 0 to 6° C.:
A method for preserving a harvested organ, a harvested organ tissue or a part thereof, which comprises perfusing and/or immersing the harvested organ, harvested organ tissue or part thereof, with a solution containing HGF having a temperature of 0 to 6° C.
A method for preserving a harvested organ, a harvested organ tissue or a part thereof for a relatively long time up to 10 hours, which comprises perfusing and/or immersing the above-mentioned harvested organ, organ tissue or part thereof, with a solution containing HGF having a temperature of 0 to 6° C.
A method for preventing a harvested organ, a harvested tissue or a part thereof from storage injury occurring during the storage of the organs before transplantation or organ failure occurring after transplantation, which comprises perfusing and/or immersing the harvested organ, harvested tissue or part thereof, with a solution containing HGF having a temperature of 0 to 6° C.
A solution used for preserving a harvested organ, a harvested organ tissue or a part thereof, comprising HGF of a temperature of 0 to 6° C. in an amount of 0.1 μg/mL to 1 mg/mL.
A solution used for perfusing and/or immersing a harvested organ, a harvested organ tissue or a part there, comprising HGF of a temperature of 0 to 6° C. in an amount of 0.1 μg/mL to 1 mg/mL.
A solution used for perfusing and/or immersing a harvested organ, a harvested organ tissue or a part there, comprising HGF of a temperature of 0 to 6° C., wherein the concentration of HGF for perfusion is 50 μg/mL to 500 μg/mL and that of HGF for immersion is 0.1 μg/mL to 50 μg/mL.
A solution used for perfusing and/or immersing a harvested organ, a harvested organ tissue or a part there, comprising HGF of a temperature of 0 to 6° C., wherein the concentration of HGF for perfusion is 1 μg/mL to 10000 μg/mL and that of HGF for immersion is 0.01 μg/mL to 1000 μg/mL.
Dependencies are inferred from the claim text.