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OwnerGreg Collier, Paul Zimmet +4inventors
InventorsGreg Collier, Paul Zimmet, Ken Walder, Janine McMillan, Andrea Sanigorski, Kelly Windmill
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The present invention relates generally to a nucleic acid molecule which is expressed in at least the stomach, hypothalamus or liver identified using differential display techniques under differing physiological conditions. It is proposed that the nucleic acid molecules encode expression products associated with the modulation of obesity, anorexia, weight maintenance, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and expression products produced by recombinant means from the nucleic acid molecule or isolated from natural sources and their use in therapeutic and diagnostic protocols for conditions such as obesity, anorexia, weight maintenance, diabetes and/or energy imbalance. The subject nucleic acid molecule and expression products and their derivatives, homologs, analogs and mimetics are proposed to be useful, therefore, as therapeutic and diagnostic agents for obesity, anorexia, weight maintenance, diabetes and/or energy imbalance or as targets for the design and/or identification of modulators of their activity and/or function.
A isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
An isolated protein encoded by a nucleic acid sequence selected from the group consisting of:
A method for modulating expression of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 in a mammal, said method comprising administering to said mammal an effective amount of a modulator of said biological molecule.
A method of modulating activity of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 in a mammal, said method comprising administering to said mammal an effective amount of a modulator of said biological molecule.
A method of treating a mammal suffering from a condition characterized by symptoms selected from the group consisting of obesity, anorexia, diabetes and energy imbalance, said method comprising administering to said mammal a composition capable of modulating the expression or activity of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504.
A method of treating a mammal suffering from a condition characterized by symptoms selected from the group consisting of obesity, anorexia, diabetes and energy imbalance, said method comprising administering to said mammal a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 or AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504.
A method of detecting a compound capable of effecting the activity of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 or AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504, said method comprising contacting said biological molecule with a candidate compound and observing the effect on the activity of said biological molecule.
A method of detecting a compound capable of effecting the expression of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 or AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504, said method comprising administering a canditate compound to a mammal and observing the effect on the expression of said biological molecule.
A composition comprising a modulator of the expression or activity of a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 and a pharmaceutically acceptable carrier or diluent.
A method for detecting a biological molecule selected from the group consisting of AGT-119, AGT-120, AGT-121, AGT-122, AGT-422, AGT-423 and AGT-504 in a biological sample, said method comprising contacting said biological sample with an antibody specific for any of said biological molecules and detecting a complex between said biological molecule and said antibody.
A isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.
An isolated protein encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.
Dependencies are inferred from the claim text.