Antifungal medicinal compositions
AssigneePola Pharma Inc.
InventorsHideaki Sasagawa, Madoka Ito, Takuji Nakashima, Akira Nozawa
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Abstract
An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
Claims18
An antifungal medicinal composition, comprising:
- (1) a film-forming agent;
- (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm;
- and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof
- wherein, R represents an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a methylene group, a lower alkenyl group, a halogen atom, a lower alkyl group substituted with a lower alkoxy group or a lower alkylthio group, or a group represented by a general formula (2) below
- wherein, R1 represents a hydrogen atom, a halogen atom, a linear- or branched-chain lower alkyl group, a lower alkoxy group, a haloalkoxy group, or a methylenedioxy group, and m represents an integral number of 1 to 3.
A method of producing an antifungal medicinal composition having (1) one or two or more selected from the group consisting of ethyl cellulose, hydroxypropyl methylcellulose phthalate, and an acrylic resin emulsion, (2) a polymer or copolymer of oxyethylene and/or oxypropylene, and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof, comprising:
- dissolving alkyl sulfate which may have a polyoxyethylene group and/or alkyl phosphate which may have a polyoxyethylene group and the polymer or copolymer of oxyethylene and/or oxypropylene in a solvent containing acetone or methyl ethyl ketone;
- adding and dissolving in the solution the one or two or more selected from the group consisting of ethyl cellulose, hydroxypropyl methylcellulose phthalate, and an acrylic resin emulsion;
- and
- adding and dissolving in the solution the antifungal compound represented by the general formula (1) and/or the physiologically acceptable salt thereof
- wherein, R represents an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a methylene group, a lower alkenyl group, a halogen atom, a lower alkyl group substituted with a lower alkoxy group or a lower alkylthio group, or a group represented by a general formula (2) below
- wherein, R1 represents a hydrogen atom, a halogen atom, a linear- or branched-chain lower alkyl group, a lower alkoxy group, a haloalkoxy group, or a methylenedioxy group, and m represents an integral number of 1 to 3.
Dependencies are inferred from the claim text.