Composition for stabilizing corneal tissue during or after orthokeratology lens wear

A method for maintaining a desired shape of corneal tissue following an orthokeratological procedure, comprising the step of:

• a. administering to a patient a stabilizing agent from a protein derived transglutaminase whereby the stabilizing agent stabilizes the corneal tissue to maintain the desired shape.

A composition comprising at least one of:

• a. fibril associated collagens with interrupted triple helices (FACITs);
• and
• b. small leucine-rich repeat proteoglycans (SLRPs).

A method for maintaining corneal curvature resulting from an orthokeratology procedure, comprising the steps of:

• a. applying a composition to a cornea to stabilize the corneal curvature by reacting with collagen fibrils, the composition being applied in an absence of administration of a corneal softening agent;
• and
• b. building bridges connecting the collagen fibrils in the cornea to constrain movement of the collagen fibrils.

A method of making a chemical composition, comprising the steps of:

• a. dissolving at least one compound chosen from fibril associated collagens with interrupted triple helices (FACITs) and small leucine-rich repeat proteoglycans (SLRPs) in a physiologically compatible solution;
• and
• b. buffering the solution to a physiologically compatible pH level.

An orthokeratological procedure to correct a patient's corneal curvature, comprising the steps of:

• a. inserting an orthokeratological lens into a patient's eye to reshape unsoftened corneal tissue of the eye in a preselected shape dictated by the orthokeratological lens;
• and
• b. applying a stabilizing agent to the patient's eye in order to stabilize the corneal tissue in the preselected area.

An orthokeratological system, comprising:

• a) an orthokeratological lens configured to be inserted into the patient's eye to reshape unsoftened corneal tissue into a preselected corneal shape dictated by the orthokeratological lens;
• and
• b) a stabilizing agent to be administered into the patient's eye to stabilize the corneal tissue in the preselected shape.