Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
AssigneeApplied Research Systems ARS Holding N.V.
InventorsGerardo Burton, Carlos Lantos, Adriana Veleiro
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Abstract
The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
Claims16
1-22. (canceled)
A method for the treatment of a disease state associated with an excess of glucocorticoid comprising
- administering a composition comprising a compound of formula (II) and at least one pharmaceutically acceptable carrier or diluent to a human in need thereof,
- wherein X is S, SO, or SO2, and R is H or OH.
A method for the treatment of a disease state associated with an excess of glucocorticoid comprising
- administering a composition comprising a compound of formula (IIa) and one or more pharmaceutically acceptable carriers or diluents to a human in need thereof,
- wherein X is SO or SO2.
Dependencies are inferred from the claim text.