Polypeptoid pulmonary surfactants
AssigneesNorthwestern University, Chiron Corporation
InventorsAnnelise Barron, Ronald Zuckermann, Cindy Wu
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
Claims21
A non-natural heteropolymeric pulmonary spreading agent comprising at least one N-substituted glycine residue and at least one amino acid residue corresponding to a natural surfactant-associated protein, said protein selected from the group consisting of surfactant-associated protein B and surfactant-associated protein C.
A pulmonary surfactant composition comprising a non-natural heteropolymeric spreading agent having at least one N-substituted glycine residue and at least one amino acid residue corresponding to a natural surfactant associated protein, said protein selected from the group consisting of surfactant-associated protein B and surfactant-associated protein C;
- and a component selected from the group consisting of naturally-occurring phospholipid, non-natural analogs of said phospholipids, commercial surface-active agents and combinations thereof, said composition having physiological alveolar surface activity.
A method of using N-substituent to enhance conformational control of a surfactant-associated protein mimic compound, said method comprising preparing a surfactant-associated protein mimic composition having at least one glycine residue, said preparation providing N-substituent of said glycine residue sufficient to enhance helical conformation of said composition.
21-31. (canceled)
Dependencies are inferred from the claim text.