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US 2005/0182274 A1Published application
Method for the production of 2,4,5-trimethylphenyl acetic acid
AssigneeBayer CropScience AG
InventorThomas Himmler
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Abstract
The present invention relates to a novel process for preparing 2,4,5-trimethylphenyl-acetic acid by reacting pseudocumene with dichloroacetyl chloride in a Friedel-Crafts reaction to give 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone, converting the 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone to 2,4,5-trimethylmandelic acid using an alkali metal hydroxide and reducing the 2,4,5-trimethylmandelic acid to 2,4,5-tri-methylphenylacetic acid.
Claims3
1-2. (canceled)
A process for preparing 2,4,5-trimethylphenylacetic acid comprising
- (a) reacting pseudocumene with dichloroacetyl chloride in a Friedel-Crafts reaction to give 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone,
- (b) converting the 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone to 2,4,5-trimethylmandelic acid using an alkali metal hydroxide, and
- (c) reducing the 2,4,5-trimethylmandelic acid to form 2,4,5-trimethylphenylacetic acid.
2,2-Dichloro-1-(2,4,5-trimethylphenyl)ethanone.
Dependencies are inferred from the claim text.