Method of preparing amine stereoisomers
AssigneeApsinterm LLC
InventorsZhengxu Han, Dhileepkumar Krishnamurthy, Chris Senanayake, Zhi-Hui Lu
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AssigneeApsinterm LLC
InventorsZhengxu Han, Dhileepkumar Krishnamurthy, Chris Senanayake, Zhi-Hui Lu
Estimating the term…
This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.
A method of preparing an amine stereoisomer, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer.
A compound of formula
A compound of formula
Dependencies are inferred from the claim text.