Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy
AssigneeBiomay Produktions- Und Handels-Aktienge Sellschaft
InventorsBirgit Simon-Nobbe, Peter Schneider, Ursula Denk, Verena Wally, Klaus Richter, Christian Radauer, Markus Teige, Christof Ebner, Michael Breitenbach
Life of this patent
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Abstract
The invention relates to polypeptides made of mannitol-dehydrogenase of Cladosporium herbarum and Alternaria alternata nucleic acids coding therefor and the use thereof in diagnosis and therapy.
Claims29
1-35. (canceled)
A vaccine for desensitizing patients to a mold allergy, comprising at least one polypeptide selected from the group consisting of (a) a polypeptide comprising at least 11 consecutive amino acids from SEQ ID No:
- 1;
- (b) a polypeptide comprising at least 11 consecutive amino acids from SEQ ID No:
- 8;
- (c) SEQ ID No:
- 4, (d) SEQ ID No:
- 5;
- (e) SEQ No:
- 6;
- and (f) a polypeptide comprising at least 11 consecutive amino acids from SEQ ID No:
- 11.
A polypeptide selected from the group consisting of (a) a polypeptide comprising at least 100 consecutive amino acids from SEQ ID No:
- 1 (b) a polypeptide comprising at least 100 consecutive amino acids from SEQ ID No:
- 8;
- (c) SEQ ID No:
- 4;
- SEQ ID No:
- 5;
- and (d) SEQ ID No:
- 6.
A polypeptide comprising at least 50 consecutive amino acids SEQ ID No:
- 11.
A polynucleotide comprising at least 50 consecutive nucleotides of SEQ ID No:
- 2, SEQ ID NO:
- 7 or SEQ ID No:
- 12.
The method detecting a mannitol dehydrogenase comprising using the polynucleotide of 52 in a nucleic acid based amplification system.
A method of detecting mannitol dehydrogenase comprising amplifying DNA using a polynucleotide comprising at least eight consecutive nucleotides from SEQ ID No:
- 2 or SEQ ID No:7 or SEQ ID No:
- 12 in a polymerase chain reaction (PCR).
Dependencies are inferred from the claim text.