Systems and methods for calibrating osmolarity measuring devices
AssigneeOcusense, Inc.
InventorsBenjamin Sullivan, Eric Donsky
Life of this patent
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Abstract
An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.
Claims26
An osmolarity measuring system, comprising:
- a sample receiving chip, the sample receiving chip comprising a sample region that includes a plurality of electrodes, the sample region configured to receive an aliquot of fluid;
- and
- a processing device coupled with the sample receiving chip, the processing device configured to measure the intrinsic conductivity for each of the plurality of electrodes, determine electrical properties for the aliquot of fluid based on signals applied to and received from the plurality of electrodes, and to calibrate the determined electrical properties using the measured intrinsic conductivities.
An osmolarity measuring system, comprising:
- a sample receiving chip, the sample receiving chip comprising a sample region that includes a plurality of electrodes, the sample region configured to receive an aliquot of fluid and a certain amount of a standard test fluid;
- and
- a processing device coupled with the sample receiving chip, the processing device configured to determine a pair-wise calibration factor for the plurality of electrodes based on signals applied to and received from the plurality of electrodes when the standard test fluid is applied to the sample region, determine electrical properties for the aliquot of fluid based on signals applied to and received from the plurality of electrodes when the aliquot of fluid is applied to the sample region, and to calibrate the determined electrical properties using the pair wise calibration factor determined for the plurality of electrodes.
Dependencies are inferred from the claim text.