Sequence analysis of the tetravalent rotavirus vaccine

An isolated nucleic acid molecule encoding a polypeptide having a sequence selected from the group consisting of:

• SEQ ID NO:15-28, inclusive.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 1 and having a nucleotide change to a G at nucleotide 2120

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 2 and having one or more of the following nucleotide changes:
• a C at nucleotide 493, and a T at nucleotide 947.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:3 and having one or more of the following nucleotide changes:

• an A at nucleotide 169, a C at nucleotide 283, a C at nucleotide 448, a C at nucleotide 874, a C at nucleotide 1306, and a C at nucleotide 2388.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:4 and having one or more of the following nucleotide changes:

• a C at nucleotide 119, a G at nucleotide 417, a G at nucleotide 809, a C at nucleotide 977, an A at nucleotide 1463, a C at nucleotide 1481, a C at nucleotide 1608, a C at nucleotide 1755, and an A at nucleotide 1953.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:5 and having one or more of the following nucleotide changes:

• an A at nucleotide 75, a T at nucleotide 84, a C at nucleotide 347, a T at nucleotide 667, a C at nucleotide 1186, a G at nucleotide 1219, and an A at nucleotide 1204.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 6 and having one or more of the following nucleotide changes:
• a C at nucleotide 376, an A at nucleotide 756, an A at nucleotide 1008, and a G at nucleotide 1041.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 7 and having a nucleotide change to a G at nucleotide 387.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:10 and having one or more of the following nucleotide changes:

• an A at nucleotide 92, an A at nucleotide 174, and a G at nucleotide 218.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 11 and having a nucleotide change to A at nucleotide 180.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 12 and having a nucleotide change to an A at nucleotide 556.

An isolated nucleic acid molecule having the sequence of SEQ ID NO:

• 14 and having a nucleotide change to a G at nucleotide 263.