Adenosylmethionine synthetase from streptomyces sp gene sequences coding the same and method for mass production for secondary metabolites including antibiotics thereof
AssigneeJoo-Won Suh
InventorsJoo-Won Suh, Young-Yell Yang, In-Hyung Lee, Dong-Jin Kim, Chang-Gu Hyun
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Abstract
Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass production of a useful secondary metabolite including antibiotics using the isolated nucleotide sequence and SAM, where SAM acts as a methyl group donor.
Claims6
(canceled)
(canceled)
A method for mass production of an antibiotic comprising over-expressing S-adenosyl-Lmethionine through over-expression of S-adenosyl-L-methionine synthetase obtained by culturing Streptomyces Lividans TK-23 harboring pSAM-s KCCM 10397 in an antibiotic-producing culture medium:
A method for mass production of an antibiotic comprising obtaining the antibiotic by culturing Streptomyces species in an antibiotic-producing culture medium containing S-adenosyl-L-methionine.
Dependencies are inferred from the claim text.