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US 2005/0112697 A1Published application
Method and apparatus for high density format screening for bioactive molecules
AssigneeBioImage A/S
InventorsBernard Terry, Kurt Scudder, Per Olaf Arkhammer, Ole Thastrup
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Abstract
A method and apparatus for screening an array of test compounds for bioactivity by contacting an array of test compounds with a detector layer capable of detecting bioactivity, and detecting a detector layer response. The detector layer is comprised of physiologically viable cells. The method and apparatus allow a large number of test compounds to be simultaneously assayed in parallel without the need for complex fluidic devices.
Claims21
A method for simultaneously exposing an array of test compounds with a detector layer,
- wherein the detector layer is overlaid by a buffer medium, whereby each test compound, upon contact, is dissolved in the buffer medium, and
- wherein each array further comprises widely spaced control points of regular control compounds which give recognizable responses;
- the method comprising the steps of:
- (a) contacting the array of test compounds held on a solid support with the detector layer through a membrane;
- (b) reading the response plate, and
- (c) using the true coordinates of these known compounds in the array to calculate a correction transformation to align points in the images of the detector layer with points in the array of compounds.
3 more elements
Dependencies are inferred from the claim text.