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OwnerStephen Prescott, A. Pearman +3inventors
InventorsStephen Prescott, A. Pearman, Hugo Castro-Faria-Neto, Diana Stafforini, Thomas McIntyre
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The present invention provides the cDNA for a novel nucleoside/nucleotide monophosphate kinase cloned from a human macrophage cDNA library. This kinase is able to phosphorylate UMP and utilize multiple phosphate donors, but has demonstrated a preference for transferring a phosphate from ATP or UTP to cytidine monophosphate (CTP). The kinase is thus referred to as cytidine monophosphate (CMP) kinase. This kinase is shown to be a Mg2+ dependent nucleotide kinase which codes for two ubiquitously transcribed mRNA splice products of 3.2 and 2.0 kb, and has been mapped to chromosome 1, region p32-34.1, a region known to contain other nucleotide modifying enzyme genes.
An isolated and purified nucleic acid molecule comprising a nucleotide sequence which encodes an amino acid sequence at least 70% identical to the amino acid sequence of SEQ ID NO:
An isolated and purified nucleic acid molecule comprising a nucleotide sequence which encodes an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:
An isolated and purified nucleic acid molecule comprising a nucleotide sequence which encodes an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:
An isolated and purified nucleic acid molecule comprising a nucleotide sequence which encodes an amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO:
An isolated and purified nucleic acid molecule comprising a nucleotide sequence which encodes the amino acid sequence of SEQ ID NO:
An isolated nucleic acid molecule which hybridizes to the complement of the nucleic acid molecule of SEQ ID NO:
Dependencies are inferred from the claim text.