Highly homogenous serum albumin as chiral selector
OwnerCarlo Bertucci, Guy Felixinventors
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Abstract
The present invention provides the use of highly homogeneous serum albumin as a chiral selector, preferably immobilised, such as in enantioselective chromatography. The present invention also provides an enantioselective chromatography column comprising, as the immobilised phase, highly homogeneous serum albumin. The present invention also provides a process for selecting an enantiomer of a chiral compound, comprising the steps of exposing a mixture of enantiomers of the compound to highly homogeneous serum albumin for a period to allow selective binding of one enantiomer to the albumin; and separating the relatively unbound enantiomer from the albumin.
Claims17
1-11. (canceled)
A method for selecting an enantiomer of a chiral compound, comprising the steps of
- (i) exposing a mixture of enantiomers of the compound to highly homogenous serum albumin for a period to allow selective binding of one enantiomer to the albumin;
- and
- (ii) separating the relatively unbound enantiomer from the albumin.
A method for increasing the purity of an agent that binds to albumin, comprising the steps of
- (i) exposing a relatively impure preparation of the agent to an affinity chromatography column comprising, in the immobilised phase, highly homogeneous serum albumin, under conditions that favour the selective binding of the agent to the albumin;
- (ii) removing unbound components of the relatively impure preparation of the agent;
- and
- (iii) eluting the agent from the affinity chromatography column to obtain a preparation of the agent with increased purity.
A method substantially as described herein with reference to the examples.
Dependencies are inferred from the claim text.