Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
AssigneeAventis Pharmaceticals, Inc.
InventorsDaniel Henton, Frederick McCarty, Susan Tripp, Jill DeWitt, Scott Peterson, William Streng
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Abstract
The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas which are useful as antihistamines, antiallergic agents and bronchodilators.
Claims27
Form I′ hydrated 4-[4[4-(hydroxydiphenylmethyl)1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form II′ hydrated 4-[4-[4(hydroxydiphenylmethyl)1-piperidinyl]1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form III′ hydrated 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form IV′ hydrated 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form V′ hydrated 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form VIII′ hydrated 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form IX′ hydrated 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
Form VII′ anhydrous 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid.
9-27. (canceled)
36-39. (canceled)
48-64. (canceled)
Dependencies are inferred from the claim text.