Production of porphyrins
OwnerClaudia Schmidt-Dannert, Arjo De Boer +1inventors
InventorsClaudia Schmidt-Dannert, Arjo De Boer, Seok Kwon
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Abstract
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.
Claims10
A microorganism comprising at least one exogenous nucleic acid encoding a 5-aminolaevulinate (ALA) synthase polypeptide, an ALA dehydratase polypeptide, a porphobilinogen deaminase polypeptide, an uroporphyrinogen III synthase polypeptide, an uroporphyrinogen decarboxylase polypeptide, a coproporphyrinogen III oxidase polypeptide, a ferrochelatase polypeptide, and a metal ion transporter polypeptide, wherein said microorganism produces an amount of Zn-protoporphyrin IX or heme that is increased relative to that of a corresponding microorganism without the at least one exogenous nucleic acid.
Dependencies are inferred from the claim text.