Apo-2 ligand
AssigneeGenentech, Inc.
InventorsAvi Ashkenazi, Ralph Schwall
Life of this patent
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Abstract
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
Claims11
1-2. (canceled)
An isolated soluble Apo-2 ligand polypeptide consisting of amino acid residues 92-281 of FIG. 1A.
4-21. (canceled)
Composition useful in treating a condition, comprising (i) an Apo-2 ligand polypeptide molecule and (ii) a DNA damaging agent sufficient to affect apoptosis.
Dependencies are inferred from the claim text.