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US 2005/0089952 A1Published application
Apparatuses and processes for increasing protein PEGylation reaction yields
AssigneeAkzo Nobel N.V.
InventorsMark Chavez, Jozef Orpiszewski
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Abstract
Embodiments of the present invention generally relate to Apparatuses and Processes for Increasing Protein PEGylation Reaction Yields through repeatable steps of PEGylation and filtration.
Claims15
A process for increasing protein PEGylation reaction yields comprising the steps of:
- i. separating an unPEGylated protein from a PEGylated species comprising the step of filtering the PEGylated protein mixture, wherein the unPEGylated protein is recovered through the permeate in initial PEGylation solution conditions and
- ii. repeating the step of separating.
A process for recovering PEGylated protein from a PEGylation reaction of unPEGylated protein comprising the steps of:
- i. PEGylating a protein through a PEGylation reaction and
- ii. filtering the PEGylated protein, wherein the unPEGylated protein is recovered in initial PEGylation solution conditions.
Dependencies are inferred from the claim text.