Compositions and methods for surrogate antibody modulation of an immune response and transport

A method of delivering an immunomodulatory agent to a ligand of interest comprising

• a) administering to a subject a composition comprising an isolated bi-functional surrogate antibody molecule comprising a specificity strand and a stabilization strand,
• said specificity strand comprising a nucleic acid sequence having a specificity region flanked by a first constant region and a second constant region;
• said stabilization strand comprises a first stabilization domain that interacts with said first constant region and a second stabilization domain that interacts with said second constant region;
• said immunomodulatory agent is attached to said bi-functional surrogate antibody molecule;
• and,
• said bi-functional surrogate antibody molecule is capable of interacting with said ligand of interest.

A method for modulating an immune response against a ligand of interest in a mammalian subject comprising

• administering to the mammalian subject an isolated bi-functional surrogate antibody molecule comprising a specificity strand and a stabilization strand,
• said specificity strand comprising a nucleic acid sequence having a specificity region flanked by a first constant region and a second constant region;
• said stabilization strand comprises a first stabilization domain that interacts with said first constant region and a second stabilization domain that interacts with said second constant region;
• and,
• said bi-functional surrogate antibody having attached thereto an immunomodulatory agent;
• and,
• said bi-functional surrogate antibody molecule is capable of interacting with said ligand of interest.