Apparatus and method for enhancing transdermal drug delivery
OwnerMichel Cormier, WeiQi Lin +2inventors
InventorsMichel Cormier, WeiQi Lin, Juanita Johnson, Kofi Nyam
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Abstract
An apparatus for transdermally delivering a biologically active agent comprising (i) a gel pack containing a hydrogel formulation and (ii) a microprojection member having top and bottom surfaces, a plurality of openings that extend through the microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of the microprojection member, the microprojection member being adapted to receive the gel pack whereby the hydrogel formulation flows through the microprojection member openings. Preferably, the hydrogel formulation comprises a water-based hydrogel.
Claims63
An apparatus for transdermally delivering a biologically active agent, comprising:
- a gel pack containing a hydrogel formulation;
- and
- a microprojection member having top and bottom surfaces, a plurality of openings that extend through said microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of said microprojection member, said microprojection member being adapted to receive said gel pack whereby said hydrogel formulation flows through said microprojection member openings.
An apparatus for transdermally delivering a biologically active agent, comprising:
- a gel pack containing a hydrogel formulation;
- a microprojection member having top and bottom surfaces, a plurality of openings that extend through said microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of said microprojection member, said microprojection member being adapted to receive said gel pack whereby said hydrogel formulation flows through said microprojection member openings;
- and
- a coating disposed on said microprojection member, said coating including a biologically active agent.
An apparatus for transdermally delivering a biologically active agent, comprising:
- a gel pack containing a hydrogel formulation;
- and
- a microprojection member having top and bottom surfaces, a plurality of openings that extend through said microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of said microprojection member, said microprojection member including a dry film having a biologically active agent.
A method of transdermally delivering a biologically active agent to a patient, the method comprising the steps of:
- providing a drug delivery apparatus having a gel pack and microprojection member, said gel pack containing a hydrogel formulation, said microprojection member having top and bottom surfaces, a plurality of openings that extend through said microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of said microprojection member, said microprojection member being adapted to receive said gel pack whereby said hydrogel formulation flows through said microprojection member openings;
- applying said microprojection member to the patient's skin;
- and
- placing said gel pack on said microprojection member after said application of said microprojection member to the patient.
A method of transdermally delivering a biologically active agent to a patient, comprising the steps of:
- providing a drug delivery apparatus having a gel pack and a microprojection member, said gel pack containing a hydrogel formulation, said microprojection member having top and bottom surfaces, a plurality of openings that extend through said microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of said microprojection member, said microprojection member being adapted to receive said gel pack whereby said hydrogel formulation flows through said microprojection member openings;
- and a coating disposed on said microprojection member, said coating including a biologically active agent;
- applying said microprojection member to the patient's skin;
- and
- placing said gel pack on said microprojection member after said application of said microprojection member to the patient.
Dependencies are inferred from the claim text.