Method of using GM-CSF to modulate food intake and regulate body weight
OwnerJacquelyn Reed, Deborah Clegg +2inventors
InventorsJacquelyn Reed, Deborah Clegg, Kathleen Smith, Randy Seeley
Life of this patent
Estimating the term…
Abstract
Methods of modulating metabolic activity and regulating body weight comprising administering to a subject an effective amount of an agent that acts via a GM-CSF signaling pathway, and methods of modulating metabolic activity and regulating body weight comprising manipulating a subject to intrinsically express an agent in an effective amount wherein the agent acts via a GM-CSF signaling pathway.
Claims47
A method for modulating metabolic activity comprising administering to a subject an agent that acts via a GM-CSF signaling pathway in an amount effective for modulating metabolic activity.
A method for modulating metabolic activity comprising manipulating a subject to express an agent in an amount effective to modulate metabolic activity wherein the agent comprises GM-CSF or acts via a GM-CSF signaling pathway.
A method for regulating body weight comprising administering to a subject an agent that acts via a signaling pathway of GM-CSF an amount effective for regulating the body weight.
A method of regulating body weight comprising manipulating a subject to express an agent in an amount effective for regulating body weight wherein the agent acts via a GM-CSF signaling pathway.
A method for treatment of idiopathic body weight disorders comprising administering to a subject an agent that acts via a GM-CSF signaling pathway in an amount effective to treat the idiopathic body weight disorder.
A method for treatment of disease-related body weight disorders comprising administering to a subject an agent that acts via a GM-CSF signaling pathway in an amount effective to treat the disease-related body weight disorder.
A method for identifying candidate compounds for regulating metabolic activity or body weight, comprising;
- a. contacting a test compound with a GM-CSF receptor;
- b. determining whether the test compound binds to the GM-CSF receptor;
- c. selecting those compounds that bind to GM-CSF receptor and further determining whether the test compound modulates metabolic activity or body weight in a model system that is capable of evaluating metabolic activity or body weight, and
- d. identifying those test compounds that modulate metabolic activity or body weight in a model system as candidate compounds for regulating metabolic activity or body weight in a species of therapeutic interest.
A method for identifying candidate compounds for regulating metabolic activity or body weight, comprising:
- a. contacting a test compound with a cell expressing a functional GM-CSF receptor,
- b. determining whether the test compound activates the GM-CSF receptor;
- c. selecting those compounds that activate the GM-CSF receptor and further determining whether the test compound modulates metabolic activity or body weight in a model system that is capable of evaluating metabolic activity or body weight, and
- d. identifying those test compounds that modulate metabolic activity or body weight as candidate compounds for regulating metabolic activity or body weight in a species of therapeutic interest.
Dependencies are inferred from the claim text.