Cationic polymers having degradable crosslinks
AssigneeNitto Denko Corporation
InventorsSheng Li, Chris Castello, Sang Van
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Abstract
A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a second degradable unit (preferably hydrolyzable). A carrier composition comprising the synthetic polymer and a bioactive agent is useful for the delivery of the bioactive agent into the nuclei of the cells.
Claims20
A synthetic polymer comprising a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit selected from the group consisting of acetal, imine and hydrazone, and at least a second degradable unit selected from the group consisting of ester, phosphoester, amide, anhydride and urethane.
Dependencies are inferred from the claim text.