Transdermal transport of compounds
OwnerSimon West, David Kannarinventors
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Abstract
There is provided a topical formulation comprising an effective skin-penetrating amount of one or more phosphate derivatives of one or more pharmaceutical hydroxy compounds and an acceptable carrier.
Claims18
A topical formulation comprising an effective skin-penetrating amount of one or more phosphate derivatives of one or more pharmaceutical hydroxy compounds and an acceptable carrier.
A method for improving skin absorption and/or maintaining adequate blood levels for prolonged periods of a pharmaceutical hydroxy compound, the method comprising the step of topically applying a formulation comprising an effective skin-penetrating amount of one or more phosphate derivatives of a pharmaceutical hydroxy compound and an acceptable carrier.
A method for hormone replacement therapy comprising topically administering to a patient a formulation comprising an effective skin penetrating amount of one or more phosphate derivatives of oestrogen and an acceptable carrier.
Use of one or more phosphate derivatives of a pharmaceutical hydroxy compound in a transdermal delivery system to improve administration to a subject of the corresponding pharmaceutical hydroxy compound.
A transdermal delivery system comprising:
- (a) a device for applying a pharmaceutical composition to skin of a subject;
- and
- (b) one or more phosphate derivatives of a pharmaceutical hydroxy compound in the device.
A method for improving the efficacy of a pharmaceutical hydroxy compound formulation, the method comprising:
- (a) forming one or more phosphate derivatives of the pharmaceutical hydroxy compound;
- and
- (b) formulating the one or more phosphate derivatives of the pharmaceutical hydroxy compound into a topical formulation;
- wherein upon administration to the skin of a subject, the one or more phosphate derivatives of the pharmaceutical hydroxy compound has improved efficacy over the corresponding non-phosphated pharmaceutical hydroxy compound formulation.
Dependencies are inferred from the claim text.