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US 2005/0053604 A1Published application
Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
AssigneePromega Corporation
InventorsJohn Kink, Katherine Worledge, Douglas Stafford
Life of this patent
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Abstract
Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human therapy for the treatment of colitis, including Crohn's disease.
Claims11
1-58. (cancelled)
A method comprising;
- a) providing;
- i) a human patient with symptoms of inflammatory bowel disease, and
- ii) a therapeutic formulation comprising antibodies purified from an avian egg yolk, wherein said antibodies are directed to human Tumor Necrosis Factor Alpha;
- and
- b) administering said formulation to the lumen of the intestine of said patient.
2 more elements
A method comprising,
- a) providing an avian egg comprising avian egg yolk and avian egg white, wherein said avian egg yolk comprises antibodies directed to human Tumor Necrosis Factor Alpha;
- b) separating said avian egg yolk from said avian egg white, and
- c) purifying said antibodies from said avian egg yolk.
Dependencies are inferred from the claim text.