Composition and method for treating neurological disorders
OwnerJohn Lyons, Lucy Changinventors
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Abstract
Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor, such as decitabine, preferably in combination with an effective amount of a histone deacetylase inhibitor. The compositions, kits and methods can be used to treat or present neurological disorders such as Lou Gehrig's disease, fragile X syndrome, Parkinson's disease and Alzheimer's disease.
Claims69
A method for treating a neurological disorder, comprising:
- administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor.
A kit for treating a neurological disorder, comprising:
- a first container containing decitabine or 5-azacytidine, and a second container containing a histone deacetylase inhibitor selected from the group consisting of hydroxamic acid, cyclic peptide, benzamide, butyrate, valproic acid and depudecin.
A method for preventing or reducing the risk of developing a neurological disorder, comprising:
- administering to an individual susceptible to the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor.
Dependencies are inferred from the claim text.