Method for producing bicalutamide
AssigneesHelm AG, CF Pharma Gyogyszergyarto KFT
InventorsAdam Bor, Gyorgy Orosz, Ferenc Lukacs, Geza Schneider
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Abstract
The invention relates to a process for preparing N-(4′-cyano-3′-trifluoromethyl)-3-(4″-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide (bicalutamide).
Claims10
A process for preparing N-(4′-cyano-3′-trifluoromethylphenyl)-3-(4″-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide (bicalutamide), characterized in that an epoxide of the general formula (I)
- in which R is a radical of the formula (II)
- or a precursor thereof is reacted with a p-fluorophenylsulfinate salt and, if R is a precursor of the radical of the formula (II), the latter is converted into a radical of the formula (II).
A process for preparing N-(4′-cyano-3′-trifluoromethylphenyl)-3-(4″-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide (bicalutamide), characterized in that a compound of the general formula (III)
- in which R is a radical of the formula (II)
- or a precursor thereof, and X is a leaving group, is reacted with a p-fluorophenylsulfinate salt and, if R is a precursor of the radical of the formula (II), the latter is converted into a radical of the formula (II).
The use of p-fluorophenylsulfinate salts for preparing bicalutamide.
Dependencies are inferred from the claim text.