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OwnerHeinz Kohler, Sybille Muller +3inventors
InventorsHeinz Kohler, Sybille Muller, Thomas Brown, Yunfeng Zhao, A. Morgan
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Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases.
A compound effective in regulating normal or infected cell function, which compound comprises an antibody, or fragment thereof, conjugated to a membrane transporter peptide, which antibody, or fragment thereof, is immmunospecific for:
A pharmaceutical composition effective in inhibiting apoptosis in a human comprising an anti-caspase antibody, or fragment thereof, conjugated to a membrane transporter peptide.
A method of treating or preventing a disease in humans comprising administering to a patient in need thereof a pharmacologically effective amount of a composition comprising an anti-caspase antibody, or fragment thereof, conjugated to a membrane transporter peptide.
An immunoconjugate comprising a membrane transporter peptide, or fragment thereof, conjugated to a secondary antibody.
A method of treating or preventing disease in humans comprising:
An in-vitro screen assay comprising:
An in-vitro screen assay comprising:
Dependencies are inferred from the claim text.