NIMA interacting proteins
AssigneeThe Salk Institute for Biological Studies
InventorsTony Hunter, Kun Ping Lu
Life of this patent
Estimating the term…
Abstract
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.
Claims28
1-3. (canceled).
An isolated nucleic acid comprising at least about 15 contiguous nucleotides of a nucleotide sequence substantially the same as nucleotides 13-129 of SEQ ID NO:
- 1, or compliment thereof.
An isolated nucleic acid comprising a nucleotide sequence substantially the same as nucleotides 13 -129 of SEQ ID NO:1.
An isolated nucleic acid comprising a nucleotide sequence encoding a portion of SEQ ID NO:2 that exhibits protein-protein association activity.
An isolated nucleic acid comprising at least about 15 contiguous nucleotides of a nucleotide sequence substantially the same as nucleotides 175-489 of SEQ ID NO:1.
An isolated nucleic acid comprising a nucleotide sequence substantially the same as nucleotides 175-489 of SEQ ID NO:1.
An isolated nucleic acid comprising a nucleotide sequence encoding a portion of SEQ ID NO:2 that exhibits PPIase activity.
Dependencies are inferred from the claim text.