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US 2005/0032907 A1Published application
Methods for preparing sertraline hydrochloride polymorphs
AssigneeRecordati Industria Chimica e Farmaceutica S.p.A.
InventorsFausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
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Abstract
This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.
Claims13
A method for preparing sertraline hydrochloride polymorphs form I, II or V, characterized in that a solution of sertraline base or a salt thereof in a suitable solvent is reacted with an amine hydrochloride, so that sertraline hydrochloride precipitates in a crystallized form.
Dependencies are inferred from the claim text.