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US 2005/0032906 A1Published application
Sertraline hydrochloride form II and methods for the preparation thereof
AssigneeRecordati Industria Chimica e Farmaceutica S.p.A.
InventorsFausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
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Abstract
This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.
Claims16
A method of selectively preparing pure sertraline hydrochloride form II, comprising the step of crystallizing sertraline hydrochloride in an acidic solution of an organic solvent selected from the group consisting of n-propanol, n-pentanol, n-hexanol, n-heptanol, n-octanol, acetonitrile, 1-methyl-2-piperidone, and mixtures thereof.
Dependencies are inferred from the claim text.