Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
AssigneeWarmer-Lambert Company LLC
InventorsHoward Ando, Donald Butler, Gary Dozeman
Life of this patent
Estimating the term…
Abstract
Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia.
Claims19
A compound that is 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt of Formula II:
- wherein R1 is C1-C4 alkyl and x is a number from 0 to 10.
(canceled).
The compound 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt hydrate.
4-6. (canceled).
8-10. (canceled).
The crystalline compound 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid mono-calcium salt methanol solvate.
12-13. (canceled).
The compound which is 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1-propyl alcohol solvate.
15-16. (canceled).
The compound which is 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid mono-calcium salt 2-propyl alcohol solvate.
18-20. (canceled).
The compound which is 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1-butyl alcohol solvate.
22-41. (canceled).
A pharmaceutical composition comprising the compound 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt together with one or more pharmaceutically acceptable diluents, carriers or excipients.
A pharmaceutical composition comprising a crystalline form 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt together with one or more pharmaceutically acceptable diluents, carriers or excipients.
44-48. (canceled).
A method of treating a vascular disease in a patient in need thereof, said method comprising administering to the patient a therapeutically effective amount of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
50-51. (canceled).
Dependencies are inferred from the claim text.