Ethylene glycol esters as photoactive agents
AssigneesQLT Inc., The University of British Columbia
InventorsEthan Sternberg, David Dolphin, Julia Levy, Anna Richter, David Hunt, Ashok Jain, Elizabeth Waterfield, Ronald Boch, Andrew Tovey
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Abstract
New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof wherein each R1 is independently alkyl (1-6C); each n is independently an integer of 0-6; and R2 is vinyl or a derivative form thereof.
Claims27
1-32.
A method for modulating the activity of a kinase involved in signal transduction in a subject in need thereof comprising irradiating said subject with light after administration of a compound of the formula
- or their 1,4-diene isomers
- or the metallated and/or labeled and/or conjugated forms thereof
- wherein each R1 is independently alkyl (1-6C);
- each n is independently an integer of 0-6;
- and
- R2 is vinyl or a derivative thereof.
Dependencies are inferred from the claim text.