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US 2005/0032702 A1Published application
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
OwnerPeter Erikssoninventor
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OwnerPeter Erikssoninventor
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Use of a substance that upon administration will lead to increased concentrations of growth hormone, such as growth hormone, a functionally equivalent analogue thereof or a substance that will increase the release of endogenous growth hormone, for the production of a medicinal product for treatment of abnormal conditions affecting neural stem cells, progenitor cells and/or cells derived from neural stem cells or progenitor cells, especially conditions affecting the oligodendroglia, astroglia, and/or neuronal cells. In vitro and in vivo methods for inducing lineage determination, propagating and/or inducing or maintaining the genesis of neurons, oligodendrocytes, astroglial cells from progenitor cells, stem cells and/or cells derived from said cells by administrating to the cells a substance that increases the concentration of growth hormone. Also a method of reducing the genesis of oligodendrocytes, neurons, astroglial cells from progenitor cells or stem cells, wherein a pharmaceutically effective amount of a substance that will lead to a decreased concentration of growth hormone or a functionally equivalent analogue thereof is administered to said patient.
1-31. (Canceled)
A method for the treatment of CNS damage affecting neural stem cells, progenitor cells and/or cells derived from stem cells or progenitor cells comprising administering an effective amount of growth hormone or a functionally equivalent analog thereof to a patient in need of such treatment.
A method for the treatment of an abnormal condition affecting the central nervous system, wherein said abnormal condition is the consequence of axonal damage caused by concussion, axonal damage caused by head trauma, axonal damage caused by small vessel disease in the CNS, damage to the spinal cord after disease and/or trauma comprising administering an effective amount of a substance to a patient whereupon administration of said substance will lead to a decreased concentration of growth hormone or a functionally equivalent analog thereof.
A method of propagating cells selected from the group consisting of neuronal progenitor cells and neuronal stem cells by administration of a composition comprising an amount of a growth hormone effective to propagate neuronal progenitor cells and neuronal stem cells in vitro.
A method of inducing lineage determination or inducing or maintaining the genesis of neurons, oligodendrocytes, astroglia cells from progenitor cells or stem cells in, or derived from, the central or peripheral nervous system in a patient, wherein a pharmaceutically effective amount of growth hormone or a functionally equivalent analogue thereof is administered to a patient in need thereof.
A method of reducing the genesis of oligodendrocytes, neurons, astroglia cells from progenitor cells or stem cells in, or derived from, the central or peripheral nervous system in a patient, wherein a pharmaceutically effective amount of a substance that will lead to a decreased concentration of growth hormone or a functionally equivalent analogue thereof is administered to a patient in need thereof.
Dependencies are inferred from the claim text.