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AssigneeClontech Laboratories, Inc.
InventorsYulii Labas, Nadezda Gurskaya, Yuriy Yanushevich, Arcady Fradkov, Konstantin Lukyanov, Sergey Lukyanov, Mikhail Matz
Estimating the term…
Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded the same, are provided. The proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins are further characterized in that they are either obtained from non-bioluminescent Cnidarian, e.g., Anthozoan, species or are obtained from Anthozoan non-Pennatulacean (sea pen) species. Specific proteins of interest include the following specific proteins: hcriGFP; dendGFP; zoanRFP; scubGFP1; scubGFP2; rfloRFP; rfloGFP; mcavRFP; mcavGFP; cgigGFP; afraGFP; rfloGFP2; mcavGFP2; and mannFP. Also of interest are proteins that are substantially similar to, or mutants of, the above specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms. The subject protein and nucleic acid compositions find use in a variety of different applications. Finally, kits for use in such applications, e.g., that include the subject nucleic acid compositions, are provided.
A nucleic acid having a sequence of residues that is substantially the same as or identical to a nucleotide sequence of at least 10 residues in length of SEQ ID NOS:01, 03, 05, 07, 09, 11, 13, 15, 17, 19, 21, 23, 25 or 27.
A nucleic acid present in other than its natural environment that encodes a chromo and/or fluorescent protein that has an amino acid sequence of:
A nucleic acid that encodes a mutant protein of a protein that has an amino acid sequence of:
Dependencies are inferred from the claim text.