Antibodies immunologically specific for PD2, a protein that is amplified and overexpressed in pancreatic cancer
AssigneeBoard of Regents of the University of Nebraska
InventorsSurinder Batra, Michael Hollingsworth
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Abstract
A human nucleic acid, PD2, its encoded protein and antibodies immunologically specific thereto are disclosed herein. The expression of the disclosed PD2 gene plays a key role in the regulation of differentiation and in the maintenance of the neoplastic state. The PD2 gene and its encoded protein represent valuable therapeutic targets in the differential diagnosis and therapy of pancreatic adenocarcinomas.
Claims10
1-27. (canceled)
An antibody immunologically specific for an isolated human PD2 protein, said human PD2 protein is about 531 amino acid in length and comprises an amino terminal helix-loop-helix domain and a centrally localized nuclear transport signal and nucleotide binding site.
Dependencies are inferred from the claim text.