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OwnerSuresh Tikoo, Alexandre Zakhartchouk +3inventors
InventorsSuresh Tikoo, Alexandre Zakhartchouk, Lorne Babiuk, Radhey Kaushik, Philip Griebel
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The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.
A chimeric adenovirus capsid protein wherein said protein comprises a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site present in a cell of gut associated lymphoid tissue (GALT) of a mammal, wherein said chimeric adenovirus capsid protein is capable of binding to the cell.
An adenovirus capsid comprising a chimeric adenovirus capsid protein.
A complex comprising a chimeric adenovirus capsid protein bound to a cell-surface binding site present in a cell of GALT of a mammal.
A method for producing a chimeric adenovirus capsid protein comprising conjugating a binding partner of a cell-surface binding site of a cell present in the GALT of a mammal to part of or all of an adenovirus capsid protein wherein said capsid protein is located on the surface of the adenovirus capsid.
Dependencies are inferred from the claim text.