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US 2005/0032031 A1Published application
Method for eliminating fragile cells from stored cells
OwnerJohn Crowe, Fern Tablin +5inventors
InventorsJohn Crowe, Fern Tablin, Nelly Tsvetkova, Zsolt Torok, Gyana Satpathy, Denis Dwyre, Rachna Bali
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Abstract
A method for reducing hemolysis in cells including washing cells in a solute solution having the capabilities of reducing cell hemolysis by at least about 0.50% for each 100 mOsm increase in osmolarity of the solute solution. A cell produced by the method for reducing hemolysis. The method permits removal of osmotically fragile cells from the population.
Claims32
A method for reducing hemolysis in cells comprising
- washing cells in a solute solution having the capabilities of reducing cell hemolysis by at least about 0.50% for each 100 mOsm increase in osmolarity of the solute solution.
A method for removing fragile cells from cells comprising:
- washing cells in a solute solution having the capabilities of reducing cell hemolysis to produce washed cells including fragile cells;
- and
- removing the fragile cells from the washed cells.
Dependencies are inferred from the claim text.