Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them

A vaccine for generating an immune response against gram-positive bacteria comprising an immunogenic amount of an amino acid sequence selected from the group consisting of ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:

• 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:
• 15), and EYAGVDIDLAKKIAK (SEQ ID NO:
• 16) and a pharmaceutically acceptable vehicle, carrier or excipient.

A method of generating an immune response comprising administering an immunogenic amount of an amino acid sequence from the group consisting of ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:

• 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:
• 15), and EYAGVDIDLAKKIAK (SEQ ID NO:
• 16) in a human or animal patient.

An isolated antibody which can recognize a surface protein from gram-positive bacteria which includes an amino acid sequence selected from the group consisting of ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:

• 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:
• 15), and EYAGVDIDLAKKIAK (SEQ ID NO:
• 16).

A vaccine for generating an immune response against gram-positive bacteria comprising an immunogenic amount of an amino acid sequence selected from the group consisting of ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:

• 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:
• 15), and EYAGVDIDLAKKIAK (SEQ ID NO:
• 16) and a pharmaceutically acceptable vehicle, carrier or excipient.

A method of generating an immune response comprising administering an immunogenic amount of a gram-positive bacterial surface protein from gram-positive bacteria which includes an amino acid sequence selected from the group consisting of ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:

• 14), VEGAVVKPVAEAYLKQN (SEQ ID NO:
• 15), and EYAGVDIDLAKKIAK (SEQ ID NO:
• 16).