Oral insulin composition and methods of making and using thereof
AssigneeTechnology Development Corporation
InventorVladimir Sabetsky
Life of this patent
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Abstract
A method of lowering blood glucose in a mammal includes orally administering a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the mammal. The composition may be a one phase or a structured multi-phase composition for controlled release of insulin.
Claims40
A method of lowering blood glucose in a mammal, comprising orally administering a therapeutically effective amount of a composition comprising crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the mammal.
A method of lowering blood glucose in a mammal, comprising orally administering a composition comprising a therapeutically effective amount of insulin and a matrix material to the mammal to lower blood glucose of the mammal by at least 5 percent 60 minutes after administering the suspension to the mammal.
A method of administering a suspension to a mammal, comprising orally administering an aqueous suspension of crystallized dextran microparticles and a therapeutically effective amount of insulin to the mammal.
A dosed pharmaceutical composition, comprising crystallized dextran microparticles and a therapeutically effective amount of insulin, wherein the composition is dosed for oral administration to a human.
A pharmaceutical composition kit, comprising:
- an aqueous suspension of crystallized dextran microparticles and a therapeutically effective amount of insulin located in a vessel;
- and
- instructions for oral administration of the composition to a human in need thereof.
A pharmaceutical kit, comprising:
- a first means for orally administering to a mammal to lower blood glucose of the mammal by at least 30 percent 60 minutes after administering the suspension to the mammal;
- and
- a storage vessel containing the first means.
A tablet comprising a pharmaceutically acceptable carrier medium, crystallized dextran microparticles and a therapeutically effective amount of insulin.
A capsule comprising a pharmaceutically acceptable shell, crystallized dextran microparticles and a therapeutically effective amount of insulin.
A method of making a dosed pharmaceutical composition, comprising:
- providing crystallized dextran microparticles;
- combining a therapeutically effective amount of insulin and the crystallized dextran microparticles in a solution after the microparticles have been crystallized to form a composition of insulin and crystallized dextran microparticles;
- and
- dosing the composition for oral administration to a mammal.
Dependencies are inferred from the claim text.