Compounds and methods for modulating desmosomal cadherin-mediated functions

(Canceled)

(Canceled)

A modulating agent that comprises a desmosomal cadherin CAR sequence selected from the group consisting of NQK, NRN, NKD, EKD, ERD, RAL, YAL, YAT, FAT and YAS, wherein the agent contains no more than 50 consecutive amino acid residues present within a desmosomal cadherin.

(Canceled)

A modulating agent comprising an antibody or antigen-binding fragment thereof that:

• (a) specifically binds to a desmoglein CAR sequence selected from the group consisting of N-Ac-IFVINQKTG-NH2 (SEQ ID NO:105), N-Ac-MFIINRNTG-NH2 (SEQ ID NO:106), N-Ac-VFYLNKDTG-NH2 (SEQ ID NO:107), N-Ac-IYRALNSMG-NH2 (SEQ ID NO:______), N-Ac-IYRALNSLG-NH2 (SEQ ID NO:______), N-Ac-LTGYALDARG-NH2 (SEQ ID NO:______), N-Ac-ITCRALNAQG-NH2 (SEQ ID NO:______) and N-Ac-ITCRALNALG-NH2 (SEQ ID NO:______);
• and
• (b) modulates a desmoglein-mediated function.

A modulating agent comprising an antibody or antigen-binding fragment thereof that:

• (a) specifically binds to a desmocollin CAR sequence selected from the group consisting of LFYIEKDTG (SEQ ID NO:545), LFYVERDTG (SEQ ID NO:559) and LFYIERDTG (SEQ ID NO:571), N-Ac-LYGYATTADG-NH2 (SEQ ID NO:______), N-Ac-LYAYATTADG-NH2 (SEQ ID NO:______), N-Ac-VYGYATTADG-NH2 (SEQ ID NO:______), N-Ac-VYAYATTADG-NH2 (SEQ ID NO:______), N-Ac-IYGYATTADG-NH2 (SEQ ID NO:______), N-Ac-IYAYATTADG-NH2 (SEQ ID NO:______), IIAFATTPDG-NH2 (SEQ ID NO:______), N-Ac-LIAFATTPDG-NH2 (SEQ ID NO:______) and N-Ac-LIAYASTADG-NH2 (SEQ ID NO:______);
• and
• (b) modulates a desmocollin-mediated function.

25-31. (Canceled)

33-39. (Canceled)

45-70. (Canceled)