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US 2004/0225136 A1Published application
Process for the preparation of 5-formylphthalide
AssigneeInfosint SA
InventorsLeone Dall'Asta, Giovanni Cotticelli
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Abstract
There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst. Furthermore, the use of 5-formylphthalide in the preparation of citalopram is described.
Claims11
A process for the preparation of 5-formylphthalide of formula
- 5
- which comprises submitting a halide of formula
- 6
- wherein Hal represents chlorine, bromine or iodine, dissolved in a dipolar aprotic solvent, to hydrogenation.
1 more element
Use of 5-formylphthalide as intermediate in the preparation of citalopram.
Dependencies are inferred from the claim text.